Understanding Cancer Metastasis

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Understanding Cancer Metastasis

Coursera (CC)
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Opleiderscore: starstarstarstar_halfstar_border 7,2 Coursera (CC) heeft een gemiddelde beoordeling van 7,2 (uit 6 ervaringen)

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Beschrijving

When you enroll for courses through Coursera you get to choose for a paid plan or for a free plan

  • Free plan: No certicification and/or audit only. You will have access to all course materials except graded items.
  • Paid plan: Commit to earning a Certificate—it's a trusted, shareable way to showcase your new skills.

About this course: Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories o…

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When you enroll for courses through Coursera you get to choose for a paid plan or for a free plan

  • Free plan: No certicification and/or audit only. You will have access to all course materials except graded items.
  • Paid plan: Commit to earning a Certificate—it's a trusted, shareable way to showcase your new skills.

About this course: Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.

Who is this class for: This course should be helpful to anyone who wants to develop a deeper understanding of cancer metastasis. It should be useful to undergraduate students who are interested in exploring the science of cancer and to health care providers, data managers, and educators who need a more thorough understanding of metastatic cancer and how it affects individuals. The course is NOT designed for patients seeking treatment guidance.

Created by:  Johns Hopkins University
  • Taught by:  Kenneth J. Pienta, M.D., The Donald S. Coffey Professor of Urology

    The James Buchanan Brady Urological Institute
  • Taught by:  Jelani Zarif, Prostate Cancer Researcher

    The James Buchanan Brady Urological Institute
  • Taught by:  Sarah Amend, Prostate Cancer Researcher

    The James Buchanan Brady Urological Institute
  • Taught by:  Haley Axelrod, Prostate Cancer Researcher

    The James Buchanan Brady Urological Institute
  • Taught by:  Kenneth Valkenburg, Prostate Cancer Researcher

    The James Buchanan Brady Urological Institute
Level Beginner Commitment 3 weeks, 1.5 hours per week Language English How To Pass Pass all graded assignments to complete the course. User Ratings 4.8 stars Average User Rating 4.8See what learners said Coursework

Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.

Help from your peers

Connect with thousands of other learners and debate ideas, discuss course material, and get help mastering concepts.

Certificates

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Johns Hopkins University The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.

Syllabus


WEEK 1


History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.


5 videos expand


  1. Video: Introduction to Understanding Cancer Metastasis
  2. Video: Introduction to History and Overview of Metastasis
  3. Video: History and Overview of Metastasis
  4. Video: History of Metastasis Theory
  5. Video: Introduction to the Sequential Steps of Metastasis

Graded: History and Overview of Metastasis

Primary Tumor Growth and Neoangiogenesis



In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.


5 videos expand


  1. Video: Introduction to Primary Tumor Growth and Neoangiogenesis
  2. Video: Tumor formation: Uncontrolled cell division
  3. Video: The role of mutations in primary tumor formation and evolution
  4. Video: Neoangiogenesis: new blood vessel formation in cancer
  5. Video: The primary tumor microenvironment: what else affects primary tumor growth?

Graded: Primary Tumor Growth and Neoangiogenesis

WEEK 2


EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.


4 videos expand


  1. Video: Introduction to EMT / Invasion / Intravasation
  2. Video: Epithelial-mesenchymal transition, invasion, and intravision
  3. Video: Local Tumor Invasion
  4. Video: Intravasation

Graded: Invasion and Intravasation

Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.


6 videos expand


  1. Video: Introduction to Survival in the Circulation and Extravasation
  2. Video: Glossary of Terms
  3. Video: The Circulation
  4. Video: How cancer cells survive while in circulation
  5. Video: Becoming a circulating tumor cell (CTC) and evading immune detection
  6. Video: Homing to a new site in the body and extravasation

Graded: Survival in the Circulation and Extravasation

WEEK 3


Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.


6 videos expand


  1. Video: Introduction to Dormancy and Secondary Tumor Growth
  2. Video: Metastatic homing
  3. Video: Evidence for cancer dormancy
  4. Video: Cancer dormancy defined
  5. Video: Properties of dormant cancer cells
  6. Video: Secondary outgrowth

Graded: Dormancy and Secondary Tumor Growth

Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.


4 videos expand


  1. Video: Introduction to Morbidity and Mortality
  2. Video: Distribution of Metastasis: Where do cancers spread?
  3. Video: Cancer Syndromes
  4. Video: Congratulations

Graded: Morbidity and Mortality Associated with Metastasis

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